一、主 题：Force-dependent interactions of biomolecules
二、主讲人：新加坡国立大学 YAN Jie 教授
五、主持人：基础与前沿研究院 赵坤 教授
Dr. Yan Jie is a single-molecule biophysicist. He obtained his PhD from the University of Illinois at Chicago in 2005. He is currently a Full Professor in the department of physics and a Principal Investigator in the Mechanobiology Institute at the National University of Singapore, where he leads research in single-molecule studies of the micromechanics of DNA and proteins. His ultimate goal is to understand how force-bearing proteins in cells are able to sense and respond to mechanical forces, and how they can be targeted through pharmaceutical means. He has been recognized for his contributions to the field, being elected as a Fellow of the American Physical Society and a Singapore NRF Investigator, and has published over 130 papers and received two patents.
Cells sense (mechanosensing) and react (mechanotransduction) to mechanical signals in their environment, which is crucial for many basic cellular functions. This mechanosensing relies on the formation of tension-transmission linkages made of non-covalently connected proteins. Cells detect dynamic tensile forces through these linkages. Protein domains and their interfaces undergo changes due to intracellular tensile forces, leading to complex connectivity of the linkages, domain alterations, and interactions among proteins in the linkage and signaling proteins in the cytosol. In my talk, I will outline the biophysical principles of force-dependent biomolecule interactions and delve into how these tension-transmission linkages could serve as a novel class of drug target.
编辑：李果 / 审核：李果 / 发布：陈伟